Endocrine Abstracts

Calcitonin is a polypeptide hormone synthesized and secreted by the parafollicular cells of the thyroid gland, and has been considered as a good marker for medullary thyroid carcinoma. But several physiologic and pathologic conditions other than medullary thyroid carcinoma have been associated with increased levels of calcitonin. A 39-year old woman was admitted to our hospital for further testing due to high calcitonin level (467 ng/L) measured by immunochemiluminometric assa...

The rarest causes of primary aldosteronism are aldosterone producing carcinoma, ectopic aldosterone secretion and familial aldosteronism. There are also few cases reported of aldosterone and cortisol tumor cosecretion. We present a 38-year-old woman admitted to our hospital because of resistant hypertension, large adrenal tumor and hypokalemia. At age 32 hypertension was diagnosed, but routine laboratory and abdominal ultrasound examination were normal. Few months before admis...

Objectives: The Clinical Activity Score (CAS) is used to measure and classify Graves orbitopathy activity (GO). However, CAS is partly subjective, and the evaluation of its components is binary. As CAS is known to be correlated with TSH receptor antibodies (TRAb), we wanted to evaluate other immunological parameters in the peripheral blood as markers of GO activity.Methods: The study included 32 patients (19 females, 13 males). CAS was evaluated by a sin...

Abstract: A 55-year-old woman was admitted to our hospital due to severe hyperthyreosis. She started to feel symptoms of hyper-metabolism four months prior to hospitalization. At that time she was admitted in regional hospital and had gastroenterological examination because of diarrhea. Crohn’s disease was diagnosed and therapy started. At the same time, thyrosupressive therapy started. She had a history of hyperthyreosis thirteen years ago, duodenal hemorrhage ulcer, hyp...

Myxoid adrenocortical adenoma is a rare adenoma originated from adrenal cortex. A 51 years old male patient was admitted to our hospital due to hypertension and hypokalemia. He has a long history of nonregulated hypertension despite multiple antihypertensive medications. Hypokalemia was detected in last two years with potassium levels around 3.0 mmol/l on high supplementation dose up to 10–16 g of KCl/day. He is obese in the past 10 years. His family history was positive...

Introduction: Glucocorticoids (GC) are the first line treatment for moderate-to-severe and active Graves’ orbitopathy (GO), but optimal treatment is still undefined. The aim of the present study was to analyze the efficacy and tolerability of combined parenteral GC pulse therapy followed by oral GC in the interpulse period.Methods: The study includes 50 patients (48±10 years; 37 females) with untreated, active and moderate-to-severe GO. Patient...

Introduction: Changes in thyroid function have significant impact on the cardiovascular system.Methods: In a group of 37 subjects the level of thyroid hormones FT4, FT3, and TSH were measured. Then carried out short-term analysis for 30 min measureing variability of blood pressure with non-invasive TASK FORCE monitor. Registered data were analyzed by spectral analysis of variability. Statistical analysis were done by Pearson correla...

Aim: The aim of this study was to compare clinical symptoms and TSH receptor antibodies (TRAb) in Graves orbitopathy (GO) in hyperthyroid patients to those patients with primarily hypothyroid and euthyroid status.Methods: Study group consisted of 54 primarily hyperthyroid (39 female, 14 male, 47±9 years) and 8 primarily hypothyroid and euthyroid patients (5 female, 3 male, 46±14 years). Clinical symptoms and TRAb were assessed. Assessment of th...

Background/objectives: The aim of the study was to assess association between diabetes mellitus (DM) and arterial hypertension (AH) in patients with adrenal incidentaloma.Design and methods: One hundred and eleven consecutive patients with incidentally discovered adrenal tumours were included in the study. OGTT was done and 24 h urinary catecholamines were measured. Aldosterone and plasma renine activity (PRA) were determined, and 1 mg dexametasone test ...

Background: Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic disease that occurs in about 10% of women in reproductive age. Today, PCOS is considered not only reproductive edocrinopathy but also a metabolic disorder associated with long-term health risks, including diabetes mellitus and cardiovascular disease.Objectives: The aim of this study was to evaluate the presense of early vascular demage in normal-weight women with polycystic ovar...